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Pontin and Reptin, Two Related ATPases with Multiple Roles in Cancer

¹ Department of Laboratory Medicine and Pathobiochemistry, Charité-Universitätsmedizin Berlin, Berlin, Germany and ² Institut National de la Santé et de la Recherche Médicale U889; and ³ Université Victor Segalen Bordeaux 2, Bordeaux, France

Requests for reprints: Jean Rosenbaum, Institut National de la Santé et de la Recherche Médicale U889, Université Victor Segalen Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux cedex, France. E-mail: jean.rosenbaum{at}gref.u-bordeaux2.fr.

Key Words: ATPase • helicase • β-catenin • c-myc • Tip60 • telomerase • SUMO

Studies in model organisms or cultured human cells suggest potential implications in carcinogenesis for the AAA+ ATPases Pontin and Reptin. Both proteins are associated with several chromatin-remodeling complexes and have many functions including transcriptional regulation, DNA damage repair, and telomerase activity. They also interact with major oncogenic actors such as β-catenin and c-myc and regulate their oncogenic function. We only now begin to get insight into the role of Pontin and Reptin in human cancers. [Cancer Res 2008;68(17):6873–6]

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