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Cancer Research 68, 7247, September 15, 2008. doi: 10.1158/0008-5472.CAN-08-0784
© 2008 American Association for Cancer Research
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Review

Tube Travel: The Role of Proteases in Individual and Collective Cancer Cell Invasion

Peter Friedl2 and Katarina Wolf1

1 Microscopical Imaging of the Cell, Department of Cell Biology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands and 2 Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg, Germany

Requests for reprints: Peter Friedl, Microscopical Imaging of the Cell, Department of Cell Biology, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, the Netherlands. Phone: +31-24-3614329; Fax: 31-24-3615317; E-mail: P.Friedl{at}ncmls.ru.nl.

Key Words: fibrosarcoma • invasion • MT1-MMP/MMP-14

Recent advances in high-resolution multimodal microscopy reveal how MT1-matrix metalloproteinase (MMP)/MMP-14 and other cell surface proteases degrade and remodel the extracellular matrix (ECM) to drive the dissemination of cancer cells into normal adjacent tissue. By cleaving collagen fibers and repatterning them into parallel bundles, individual cells reorient the ECM to permit movement in tube-like microtracks. Cells along the edge of these tubes can excavate ECM outward, generating macrotracks through which collective mass movement of cancer cells can occur. These findings develop our understanding of invasive processes in cancer and how to attack them by interfering with MMP-14 activity. [Cancer Res 2008;68(18):7247–9]




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