This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hadamitzky, C. Articles by Pabst, R. Search for Related Content PubMed PubMed Citation Articles by Hadamitzky, C. Articles by Pabst, R. Related Collections Tumor Biology Tumor Biology: Model Organisms and Imaging

Acquired Lymphedema: An Urgent Need for Adequate Animal Models

Department of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany

Requests for reprints: Catarina Hadamitzky, Department of Functional and Applied Anatomy, Hannover Medical School, Carl-Neuberg-Str. 1 30625 Hannover, Germany. Phone: 49-511-532-6742; Fax: 49-511-532-2948; E-mail: Hadamitzky.Catarina{at}MH-Hannover.de.

In cancer patients, the removal of tumor-draining lymph nodes during tumor resection can lead to acquired lymphedema. This disease, which is characterized by tissue swelling and increased risk of infection due to restricted lymph flow, lacks an effective treatment. Limitations to the design and conduct of randomized trials to date have limited the evaluation of proposed surgical techniques. As a result, animal models have provided an important research base. This review summarizes work in canine, rabbit, and rodent models of acquired lymphedema, focusing on arising limitations and potential applications. [Cancer Res 2008;68(2):343–5]

This article has been cited by other articles:

				G. C. Prendergast Cancer Management Hatches New Research Problems Cancer Reviews Online Content, February 1, 2008; 2008(2): 3 - 3. [Full Text] [PDF]