This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Brown, S. L. Articles by Freeman, M. L. Search for Related Content PubMed PubMed Citation Articles by Brown, S. L. Articles by Freeman, M. L.

Activating Transcription Factor 3 Is a Novel Repressor of the Nuclear Factor Erythroid-Derived 2–Related Factor 2 (Nrf2)–Regulated Stress Pathway

Department of Radiation Oncology and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee

Requests for reprints: Michael L. Freeman, Radiation Oncology, Vanderbilt University School of Medicine, B 902 TVC, Nashville, TN 37232. Phone: 615-322-3606; Fax: 615-343-3061; E-mail: michael.freeman{at}vanderbilt.edu.

The transcription factor nuclear factor erythroid-derived 2–related factor 2 (Nrf2) regulates induction of an extensive cellular stress response network when complexed with the cAMP-responsive element binding protein (CBP) at antioxidant response elements (ARE) located in the promoter region of target genes. Activating transcription factor 3 (ATF3) can repress Nrf2-mediated signaling in a manner that is not well understood. Here, we show that ATF3-mediated suppression is a consequence of direct ATF3-Nrf2 protein-protein interactions that result in displacement of CBP from the ARE. This work establishes ATF3 as a novel repressor of the Nrf2-directed stress response pathway. [Cancer Res 2008;68(2):364–8]

This article has been cited by other articles:

				K.-H. Kim, J.-Y. Jeong, Y.-J. Surh, and K.-W. Kim Expression of stress-response ATF3 is mediated by Nrf2 in astrocytes Nucleic Acids Res., October 28, 2009; (2009) gkp865v1. [Abstract] [Full Text] [PDF]

				M. Kawai, Y. Saegusa, M. Jin, Y. Dewa, J. Nishimura, T. Harada, M. Shibutani, and K. Mitsumori Mechanistic Study on Hepatocarcinogenesis of Piperonyl Butoxide in Mice Toxicol Pathol, October 1, 2009; 37(6): 761 - 769. [Abstract] [Full Text] [PDF]