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Emerging Role of miR-106b-25/miR-17-92 Clusters in the Control of Transforming Growth Factor β Signaling

Department of Molecular Virology, Immunology and Medical Genetics, Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio

Requests for reprints: Carlo M. Croce, Department of Molecular Virology, Immunology and Medical Genetics, Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, 460 West 12th Avenue, Columbus, OH 43210. Phone: 614-292-4930; Fax: 614-292-3558; E-mail: carlo.croce{at}osumc.edu.

Key Words: gene targets • microRNAs • TGFβ

Inactivation of the transforming growth factor β (TGFβ) tumor suppressor pathway is a main step in the development of a variety of human tumors. The miR-106b-25 and miR-17-92 clusters are emerging as key modulators of TGFβ signaling in gastrointestinal and other tumors, interfering with cell cycle arrest and apoptosis when overexpressed in cancer cells. Genetic ablation of these microRNAs (miRNAs) reveals their physiologic role in the control of liver and central nervous system apoptosis, supporting the notion that miRNA-based homeostatic mechanisms can be usurped by cancer cells to resist TGFβ tumor suppression. [Cancer Res 2008;68(20):8191–4]

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