This Article Full Text Full Text (PDF) Supplementary Data Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Song, H. Articles by Pharoah, P. D.P. Search for Related Content PubMed PubMed Citation Articles by Song, H. Articles by Pharoah, P. D.P.

Association Study of Prostate Cancer Susceptibility Variants with Risks of Invasive Ovarian, Breast, and Colorectal Cancer

¹ CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, ² Cancer Research UK Cambridge Cancer Research Institute, and ³ CR-UK Genetic Epidemiology Unit, University of Cambridge, Strangeways Research Laboratory, Cambridge, United Kingdom; ⁴ Department of Viruses, Hormones, and Cancer, Institute of Cancer Epidemiology, Danish Cancer Society and ⁵ Juliane Marie Centre, Copenhagen University Hospital, Copenhagen, Denmark; ⁶ Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York; ⁷ Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California; and ⁸ Gynaecological Cancer Research Laboratories, UCL EGA Institute for Women's Health, University College London, ⁹ Section of Cancer Genetics, Institute of Cancer Research, and ¹⁰ The Royal Marsden NHS Foundation Trust, London, United Kingdom

Requests for reprints: Honglin Song, Strangeways Research Laboratory, Department of Oncology, University of Cambridge, Worts Causewasy, Cb1 8RN, Cambridge, UK. Phone: 44-1223-740161; Fax: 44-1223-740147; E-mail: honglin{at}srl.cam.ac.uk.

Key Words: prostate cancer susceptibility • SNP • ovarian cancer • breast cancer • colorectal cancer

Several prostate cancer susceptibility loci have recently been identified by genome-wide association studies. These loci are candidates for susceptibility to other epithelial cancers. The aim of this study was to test these tag single nucleotide polymorphisms (SNP) for association with invasive ovarian, colorectal, and breast cancer. Twelve prostate cancer–associated tag SNPs were genotyped in ovarian (2,087 cases/3,491 controls), colorectal (2,148 cases/2,265 controls) and breast (first set, 4,339 cases/4,552 controls; second set, 3,800 cases/3,995 controls) case-control studies. The primary test of association was a comparison of genotype frequencies between cases and controls, and a test for trend stratified by study where appropriate. Genotype-specific odds ratios (OR) were estimated by logistic regression. SNP rs2660753 (chromosome 3p12) showed evidence of association with ovarian cancer [per minor allele OR, 1.19; 95% confidence interval (95% CI), 1.04–1.37; P_trend = 0.012]. This association was stronger for the serous histologic subtype (OR, 1.29; 95% CI, 1.09–1.53; P = 0.003). SNP rs7931342 (chromosome 11q13) showed some evidence of association with breast cancer (per minor allele OR, 0.95; 95% CI, 0.91–0.99; P_trend = 0.028). This association was somewhat stronger for estrogen receptor–positive tumors (OR, 0.92; 95% CI, 0.87–0.98; P = 0.011). None of these tag SNPs were associated with risk of colorectal cancer. In conclusion, loci associated with risk of prostate cancer may also be associated with ovarian and breast cancer susceptibility. However, the effects are modest and warrant replication in larger studies. [Cancer Res 2008;68(21):8837–42]

This article has been cited by other articles:

				F. J. Couch, X. Wang, R. R. McWilliams, W. R. Bamlet, M. de Andrade, and G. M. Petersen Association of Breast Cancer Susceptibility Variants with Risk of Pancreatic Cancer Cancer Epidemiol. Biomarkers Prev., November 1, 2009; 18(11): 3044 - 3048. [Abstract] [Full Text] [PDF]