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Does the Renin-Angiotensin System Participate in Regulation of Human Vasculogenesis and Angiogenesis?

¹ The University of Texas M. D. Anderson Cancer Center, Houston, Texas and ² Harvard Medical School and Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, Massachusetts

Requests for reprints: Wadih Arap or Renata Pasqualini, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030. Phone: 713-792-3873; Fax: 713-745-2999; E-mail: warap{at}mdanderson.org or rpasqual{at}mdanderson.org.

Key Words: angiogenesis • angiotensin • hypertension

Several lines of evidence suggest that hypertension and angiogenesis may be related phenomena but a functional link remains elusive. Here, we propose that the renin-angiotensin system (RAS), in addition to its central role in arterial hypertension, also regulates blood vessel formation during normal development and cancer. This mechanistic hypothesis is based on reports of biochemical, genetic, clinical, and epidemiologic data reviewed herein. Species differences between the RAS of rodents and humans likely account for why such a fundamental role in angiogenesis went unrecognized for so long. If proven correct, this hypothesis carries many implications for the medical practices of cardiology, oncology, and neonatology. [Cancer Res 2008;68(22):9112–5]

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