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Cancer Research 68, 9116, November 15, 2008. doi: 10.1158/0008-5472.CAN-08-2184
© 2008 American Association for Cancer Research
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Perspectives in Cancer Research

The Role of Parental and Grandparental Epigenetic Alterations in Familial Cancer Risk

Jessica L. Fleming1, Tim H-M. Huang1 and Amanda Ewart Toland1,2

1 Human Cancer Genetics Program and the Ohio State Comprehensive Cancer Center, Department of Molecular Virology, Immunology, and Medical Genetics, and 2 Department of Internal Medicine, The Ohio State University, Columbus, Ohio

Requests for reprints: Amanda Ewart Toland, 998 BRT, 460 West 12th Avenue, Columbus, OH 43210. Phone: 614-247-8185; Fax: 614-688-8675; E-mail: amanda.toland{at}osumc.edu.

Key Words: epigenetics • transgenerational epigenetic inheritance • MLH1 • MSH2

Abstract

Epigenetic alterations of the genome such as DNA promoter methylation and chromatin remodeling play an important role in tumorigenesis. These modifications take place throughout development with subsequent events occurring later in adulthood. Recent studies, however, suggest that some epigenetic alterations that influence cancer risk are inherited through the germline from parent to child and are observed in multiple generations. Epigenetic changes may be inherited as Mendelian, non-Mendelian, or environmentally induced traits. Here, we will discuss Mendelian, non-Mendelian, and environmentally induced patterns of multigenerational epigenetic alterations as well as some possible mechanisms for how these events may be occurring. [Cancer Res 2008;68(22):9116–21]




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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
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Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2008 by the American Association for Cancer Research.