This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Zhang, B. Search for Related Content PubMed PubMed Citation Articles by Zhang, B. Related Collections Cancer Immunology Cancer Immunology: Adaptive Immunity

Targeting the Stroma by T Cells to Limit Tumor Growth

The Department of Medicine-Division of Hematology & Medical Oncology, Cancer Therapy & Research Center, University of Texas Health Science Center, San Antonio, Texas

Requests for reprints: Bin Zhang, Cancer Therapy and Research Center, University of Texas Health Sciences Center, 2040 Babcock Road, Suite 201, San Antonio, TX 78229. Phone: 210-562-5243; Fax: 7210-562-5292; E-mail: Zhangb3{at}uthscsa.edu.

Solid tumors may modulate their environment and keep stromal cells in an immunosuppressive and tumor-promoting state. Recent findings indicate that targeting not only cancer cells but also nonmalignant stromal cells by T cells is required for the eradication of established tumor. Interestingly, a single adoptive transfer of effector T cells that recognize tumor antigen-loaded stromal cells, but not the cancer cells themselves, causes long-term inhibition of tumor growth associated with T cell–mediated killing of stromal CD11b⁺/Gr1⁺ myeloid cells. Therefore, targeting tumor stroma by T cells points to an important alternative approach to the effective control of tumor growth, particularly in the absence of direct targeting of cancer cells. [Cancer Res 2008;68(23):9570–3]

This article has been cited by other articles:

				D. Peruzzi, F. Mori, A. Conforti, D. Lazzaro, E. De Rinaldis, G. Ciliberto, N. La Monica, and L. Aurisicchio MMP11: A Novel Target Antigen for Cancer Immunotherapy Clin. Cancer Res., June 15, 2009; 15(12): 4104 - 4113. [Abstract] [Full Text] [PDF]

				G. C. Prendergast New Ideas in Cancer Etiology and Therapy: Fetal Microchimerism and Eradication of Tumor Stroma Cancer Reviews Online Content, January 1, 2009; 2009(1): 1 - 1. [Full Text] [PDF]