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A Range of Cancers Is Associated with the rs6983267 Marker on Chromosome 8

Dominika Wokoorczyk¹, Bartomiej Gliniewicz², Andrzej Sikorski², Elbieta Zowocka¹, Bartomiej Masoj¹, Tadeusz Dbniak¹, Joanna Matyjasik¹, Marek Mierzejewski¹, Krzysztof Mdrek¹, Dorota Oszutowska¹, Janina Suchy¹, Jacek Gronwald¹, Urszula Teodorczyk¹, Tomasz Huzarski¹, Tomasz Byrski¹, Anna Jakubowska¹, Bohdan Górski¹, Thierry van de Wetering¹, Swietana Walczak¹, Steven A. Narod³, Jan Lubiski¹ and Cezary Cybulski¹

¹ International Hereditary Cancer Center, Department of Genetics and Pathology and ² Clinic of Urology, Pomeranian Medical University, Szczecin, Poland; and ³ Womens College Research Institute, Toronto, Ontario, Canada

Requests for reprints: Cezary Cybulski, International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, ul. Poabska 4, 70-115 Szczecin, Poland. Phone: 48-91-466-1532; Fax: 48-91-466-1533; E-mail: cezarycy{at}sci.pam.szczecin.pl.

Key Words: chromosome 8q24 • rs6983267 • hereditary • cancer

Several genome-wide searches for common cancers have lead to the identification of a small number of loci that harbor low-risk cancer susceptibility markers. One marker, rs6983267 on chromosome 8q24, has been linked to both colon and prostate cancer, and is therefore a good candidate for a multicancer susceptibility marker. To determine the range of cancer sites associated with rs6983267, we genotyped 7,665 cases of cancer, representing 11 common cancer sites, and 1,910 controls. A significant odds ratio (OR) was observed for prostate cancer for carriers of genotype GG [OR, 1.77; 95% confidence interval (CI), 1.47–2.13]. The homozygote OR was higher for tumors with Gleason score 8 to 10 (OR, 1.94; 95% CI, 1.18–3.20) than for tumors with Gleason score 7 and below (OR, 1.65; 95% CI, 1.31–2.08). Significantly elevated (homozygote) ORs were observed for 4 other cancer sites, including colon (OR, 1.36; 95% CI, 1.08–1.72), kidney (OR, 1.52; 95% CI, 1.12–2.05), thyroid (OR, 1.37; 95% CI, 1.02–1.82), and larynx (OR, 1.39; 95% CI, 1.02–1.90). Information was available on family histories of cancer for eight sites. For six of the eight sites (prostate, breast, bladder, larynx, lung, and kidney), the homozygote ORs were higher for cases with a positive family history (at least one first-degree with any cancer) than for cases with unaffected first-degree relatives. Our results suggest that the range of cancers associated with the rs6983267 marker might be larger than previously thought. [Cancer Res 2008;68(23):9982–6]

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