This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lindemann, R. K. Search for Related Content PubMed PubMed Citation Articles by Lindemann, R. K. Related Collections Cellular Pathobiology Cellular Pathobiology: Proliferation, Senescence, and Death Therapeutics and Targets: Identification, Validation, and Markers

Stroma-Initiated Hedgehog Signaling Takes Center Stage in B-Cell Lymphoma

National Center for Tumor Diseases, Department of Translational Oncology G100, Heidelberg, Germany

Requests for reprints: Ralph K. Lindemann, National Center for Tumor Diseases, Department of Translational Oncology G100, Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany. Phone: 49-6221-421602; Fax: 49-6221-421611; E-mail: ralph.lindemann{at}nct-heidelberg.de.

Hedgehog-mediated signaling has been shown to promote growth and dissemination of solid cancers, most prominently basal cell carcinomas and medulloblastoma. Recent findings indicate that hedgehog signals are also important for tumor growth in hematologic malignancies. Hedgehog ligands secreted by stromal cells could elicit Patched/Smoothened-mediated antiapoptotic signaling in mouse B-cell lymphomas. Inhibition of hedgehog signaling induced apoptosis in lymphoma cells and prolonged survival of lymphoma-bearing mice. Depletion of tumor cells proceeded in the absence of p53 via the mitochondrial apoptotic pathway. These and other recently published data on hedgehog inhibition in cancer cells and their implications will be discussed. [Cancer Res 2008;68(4):961–4]

This article has been cited by other articles:

				J. Xie Activation of Hedgehog Signaling in Human Cancer: Basic Mechanisms and Clinical Implications Am. Assoc. Cancer Res. Educ. Book, April 18, 2009; 2009(1): 25 - 41. [Full Text] [PDF]

				G. V. Hegde, K. J. Peterson, K. Emanuel, A. K. Mittal, A. D. Joshi, J. D. Dickinson, G. J. Kollessery, R. G. Bociek, P. Bierman, J. M. Vose, et al. Hedgehog-Induced Survival of B-Cell Chronic Lymphocytic Leukemia Cells in a Stromal Cell Microenvironment: A Potential New Therapeutic Target Mol. Cancer Res., December 1, 2008; 6(12): 1928 - 1936. [Abstract] [Full Text] [PDF]

				G. V. Hegde, C. M. Munger, K. Emanuel, A. D. Joshi, T. C. Greiner, D. D. Weisenburger, J. M. Vose, and S. S. Joshi Targeting of sonic hedgehog-GLI signaling: a potential strategy to improve therapy for mantle cell lymphoma Mol. Cancer Ther., June 1, 2008; 7(6): 1450 - 1460. [Abstract] [Full Text] [PDF]

				G. C. Prendergast Murder or Suicide: Strategies to Selectively Eliminate Cancer Cells Cancer Reviews Online Content, March 1, 2008; 2008(3): 5 - 6. [Full Text] [PDF]