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Cancer Research 68, 1347, March 1, 2008. doi: 10.1158/0008-5472.CAN-07-6067
© 2008 American Association for Cancer Research

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Molecular Biology, Pathobiology, and Genetics

Mouse Models for Xeroderma Pigmentosum Group A and Group C Show Divergent Cancer Phenotypes

Joost P.M. Melis1, Susan W.P. Wijnhoven1, Rudolf B. Beems1, Marianne Roodbergen1, Jolanda van den Berg1, Hojin Moon2, Errol Friedberg3, Gijsbertus T.J. van der Horst4, Jan H.J. Hoeijmakers4, Jan Vijg5 and Harry van Steeg1

1 National Institute of Public Health and the Environment (RIVM), Laboratory for Health Protection Research, Bilthoven, the Netherlands; 2 Department of Mathematics and Statistics, California State University, Long Beach, California; 3 Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas; 4 MGC-Department of Cell Biology and Genetics, Center for Biomedical Genetics, Erasmus University Medical Center, Rotterdam, the Netherlands; and 5 Buck Institute for Age Research, Novato, California

Requests for reprints: Harry van Steeg, Laboratory for Health Protection Research, National Institute of Public Health and the Environment, P.O. Box 1, 3720 BA Bilthoven, the Netherlands. Phone: 31-30-274-2102; Fax: 31-30-274-4446; E-mail: Harry.van.Steeg{at}rivm.nl.

Key Words: Mouse longevity study • Pathology features • Oxidative damage lung • Xpa and Xpc • DNA Repair and NER

The accumulation of DNA damage is a slow but hazardous phenomenon that may lead to cell death, accelerated aging, and cancer. One of the most versatile defense mechanisms against the accumulation of DNA damage is nucleotide excision repair, in which, among others, the Xeroderma pigmentosum group C (XPC) and group A (XPA) proteins are involved. To elucidate differences in the functions of these two proteins, comprehensive survival studies with Xpa–/–, Xpc–/– and wild-type control female mice in a pure C57BL/6J background were done. The median survival of Xpc–/– mice showed a significant decrease, whereas the median survival of Xpa–/– mice did not. Strikingly, Xpa–/– and Xpc–/– mice also showed a phenotypical difference in terms of tumor spectrum. Xpc–/– mice displayed a significant increase in lung tumors and a trend toward increased liver tumors compared with Xpa-deficient or wild-type mice. Xpa–/– mice showed a significant elevation in liver tumors. Additionally, Xpc-deficient mice exhibited a strong increase in mutant frequency in lung compared with Xpa–/– mice, whereas in both models mutant frequency is increased in liver. Our in vitro data displayed an elevated sensitivity to oxygen in Xpc–/– in mouse embryonic fibroblasts (MEF) when compared with Xpa–/– and wild-type fibroblasts. We believe that XPC plays a role in the removal of oxidative DNA damage and that, therefore, Xpc–/– mice display a significant increase in lung tumors and a significant elevation in mutant frequency in lung, and Xpc-deficient MEFs show greater sensitivity to oxygen when compared with Xpa–/– and wild-type mice. [Cancer Res 2008;68(5):1347–53]




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