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Department of Microbiology and Immunology, and the Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, New Hampshire
Requests for reprints: Mary Jo Turk, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756. Phone: 603-653-3549; Fax: 603-653-9952; E-mail: mary.jo.turk{at}dartmouth.edu.
Key Words: T-cell memory tumors regulatory T cells CD8 T cells surgery melanoma
Antitumor immune responses can be stimulated by interfering with regulatory T-cell (Treg) function. However, this effect is short lived unless T-cell memory to tumor antigens can be generated. Our recent studies show that Treg cells not only limit primary responses to tumor/self-antigens in tumor-bearing hosts but also prevent the natural generation of T-cell memory to such antigens. Here, we discuss the role of Treg cells in suppressing T-cell memory after surgical excision of tumors and the potential clinical benefits of overcoming this suppression. [Cancer Res 2008;68(6):1614–7]
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