This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bagchi, A. Articles by Mills, A. A. Search for Related Content PubMed PubMed Citation Articles by Bagchi, A. Articles by Mills, A. A. Related Collections Cellular Pathobiology Cellular Pathobiology: Cancer Genes and Genomics

The Quest for the 1p36 Tumor Suppressor

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York

Requests for reprints: Alea A. Mills, Cold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, NY 11724. Phone: 516-367-6910; E-mail: mills{at}cshl.edu.

Key Words: 1p36 • CHD5 • chromosome engineering • p53 • Ink4/Arf

Genomic analyses of late-stage human cancers have uncovered deletions encompassing 1p36, thereby providing an extensive body of literature supporting the idea that a potent tumor suppressor resides in this interval. Although several genes have been proposed as 1p36 candidate tumor suppressors, convincing evidence that their encoded products protect from cancer has been scanty. A recent functional study identified chromodomain helicase DNA-binding protein 5 (CHD5) as a novel tumor suppressor mapping to 1p36. Here, we discuss evidence supporting the tumor-suppressive role of CHD5. Together, these findings suggest that strategies designed to enhance CHD5 activity could provide novel approaches for treating a broad range of human malignancies. [Cancer Res 2008;68(8):2551–6]

This article has been cited by other articles:

				M. Pigazzi, E. Manara, E. Baron, and G. Basso miR-34b Targets Cyclic AMP-Responsive Element Binding Protein in Acute Myeloid Leukemia Cancer Res., March 15, 2009; 69(6): 2471 - 2478. [Abstract] [Full Text] [PDF]

				G. C. Prendergast Risk Factors for Cancer: From Cell to Microenvironment Cancer Reviews Online Content, May 1, 2008; 2008(5): 9 - 9. [Full Text] [PDF]