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Tumor Escape Mechanism Governed by Myeloid-Derived Suppressor Cells

H. Lee Moffitt Cancer Center, University of South Florida, Tampa, Florida

Requests for reprints: Dmitry Gabrilovich, H. Lee Moffitt Cancer Center, University of South Florida, MRC-2, Room 2067, 12902 Magnolia Drive, Tampa, FL 33612. Phone: 813-903-6863; Fax: 813-632-1328; E-mail: dmitry.gabrilovich{at}moffitt.org.

Key Words: immune suppression • T cells • tumor immunology

T-cell nonresponsiveness is a critical factor in immune escape and myeloid-derived suppressor cells play a major role in organizing this phenomenon. Recent findings indicate that myeloid-derived suppressor cells can induce antigen-specific CD8⁺ T-cell tolerance through a posttranslation mechanism which involves modification (nitration) of CD8 and the T-cell receptor itself on the T-cell surface. Elucidation of this mechanism of T-cell tolerance offers new opportunities for therapeutic corrections of immune escape in cancer. [Cancer Res 2008;68(8):2561–63]

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