This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Karan, D. Articles by Thrasher, J. B. Search for Related Content PubMed PubMed Citation Articles by Karan, D. Articles by Thrasher, J. B. Related Collections Tumor Biology Tumor Biology: Inflammation and Immune Escape

Macrophage Inhibitory Cytokine-1: Possible Bridge Molecule of Inflammation and Prostate Cancer

¹ Veterans Affairs Medical Center, Kansas City, Missouri; and ² Department of Urology, University of Kansas Medical Center, Kansas City, Kansas

Requests for reprints: Dev Karan, Research Services, Veterans Affairs Medical Center, 4801 Linwood Boulevard, Kansas City, MO 64128. Phone: 913-945-6670/816-861-6451; Fax: 913-588-6195/816-861-1110; E-mail: dkaran{at}kumc.edu.

Key Words: Inflammation • MIC-1 • Prostate cancer

There is emerging evidence that inflammation may lead to prostate cancer development. Although inflammation is an essential response to injury or infection, chronic inflammation is harmful and causes tissue damage. Increasing evidence suggests that inflammation leads to the development of epithelial cancers; however, studies on inflammation-targeted genes that might contribute to the development of cancer are at the beginning stage. Here, we describe macrophage inhibitory cytokine-1, which provides a potential link between inflammation and prostate cancer. Understanding the regulation of macrophage inhibitory cytokine-1 in response to inflammation may have potential for novel therapeutic strategies. [Cancer Res 2009;69(1):2–5]

This article has been cited by other articles:

				A. Moreno-Aspitia and E. A. Perez Treatment Options for Breast Cancer Resistant to Anthracycline and Taxane Mayo Clin. Proc., June 1, 2009; 84(6): 533 - 545. [Abstract] [Full Text] [PDF]