This Article Full Text Full Text (PDF) All Versions of this Article: 0008-5472.CAN-09-0176v1 69/15/6011    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sun, T. Articles by Lin, D. Search for Related Content PubMed PubMed Citation Articles by Sun, T. Articles by Lin, D. Related Collections Epidemiology and Prevention Epidemiology and Prevention: Genetics and Biomarkers Cancer Immunology: Adaptive Immunity

Genetic Polymorphisms in Cytotoxic T-Lymphocyte Antigen 4 and Cancer: The Dialectical Nature of Subtle Human Immune Dysregulation

¹ Department of Etiology and Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China and ² Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing, China

Requests for reprints: Dongxin Lin, Department of Etiology and Carcinogenesis, Cancer Institute, Chinese Academy of Medical Sciences, Beijing 100021, China. Phone: 8610-877-88491; Fax: 8610-677-22460; E-mail: lindx72{at}cicams.ac.cn.

Genetic polymorphisms in the human genome are an important component of genotypic variability including one's immune status. Single nucleotide polymorphisms (SNPs) in the cytotoxic T-lymphocyte antigen 4 (CTLA-4) gene have been linked to susceptibility to autoimmune disease. Interestingly, we have recently shown that an SNP in the CTLA-4 coding region (49A > G) is also associated with susceptibility to human cancer, but the risk allele for susceptibility to cancer (allele A) is the opposite of that found for susceptibility to autoimmune disease (allele G), which has been confirmed by a meta-analysis of reported studies. These findings indicate an important role of the dialectical nature of T-cell immune dysregulation in human disorders, such as autoimmune disease and cancer. The requisites of CTLA-4 polymorphisms for susceptibility to cancer and response to targeted therapy are discussed in this review. [Cancer Res 2009;69(15):6011–4]

This article has been cited by other articles:

				G. C. Prendergast Unifying Insights into Cancer Cell Signaling: Hedgehog, Cell Polarity, Complement, and CTLA-4 Polymorphisms Cancer Reviews Online Content, January 1, 2009; 2009(9): 17 - 18. [Full Text] [PDF]