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c-Myc and eIF4F Constitute a Feedforward Loop That Regulates Cell Growth: Implications for Anticancer Therapy

¹ Department of Biochemistry and ² McGill Cancer Center, McIntyre Medical Sciences Building, McGill University, Montreal, Quebec, Canada

Requests for reprints: Jerry Pelletier, McIntyre Medical Sciences Building, Room 810, 3655 Promenade Sir William Osler, McGill University, Montreal, Quebec, H3G 1Y6, Canada. Phone: 514-398-2323; Fax: 514-398-7384; E-mail: jerry.pelletier{at}mcgill.ca.

The Myc/Max/Mad family of transcription factors and the eukaryotic initiation factor 4F (4F) complex play fundamental roles in regulating cell growth, proliferation, differentiation, and oncogenic transformation. Recent findings indicate that the role of Myc during cell growth and proliferation is linked to an increase in eIF4F activity in a feedforward relationship, providing a possible molecular mechanism of cell transformation by Myc. Developing therapeutics to inhibit eIF4F and/or Myc could be a potential treatment for a wide range of human cancers. [Cancer Res 2009;69(19):7491–4]