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On the Role of Cell Signaling Models in Cancer Research

University of Michigan, Ann Arbor, Michigan

Requests for reprints: Sofia D. Merajver, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI 48109. Phone: 734-936-6884; Fax: 1-734-936-7376; E-mail: smerajve{at}umich.edu.

Key Words: cancer-targeted therapies • cell signaling • mathematical modeling

The main objective of this review is to emphasize the role and importance of the careful mathematical/computational modeling of signaling networks for the understanding of aberrant signaling in cancer and for the development of targeted therapies. [Cancer Res 2009;69(2):400–2]

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