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Cancer Research 69, 758, February 1, 2009. Published Online First January 20, 2009;
doi: 10.1158/0008-5472.CAN-08-2984
© 2009 American Association for Cancer Research
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Priority Reports

Large-Scale Profiling of Archival Lymph Nodes Reveals Pervasive Remodeling of the Follicular Lymphoma Methylome

J. Keith Killian1,2, Sven Bilke1, Sean Davis1, Robert L. Walker1, M. Scott Killian5, Erich B. Jaeger4, Yidong Chen1, Jason Hipp2, Stefania Pittaluga2, Mark Raffeld2, Robert Cornelison1, William I. Smith,, Jr.3, Marina Bibikova4, Jian-Bing Fan4, Michael R. Emmert-Buck2, Elaine S. Jaffe2 and Paul S. Meltzer1

1 Genetics Branch and 2 Laboratory of Pathology, NIH/National Cancer Institute; 3 Pathology Department, Suburban Hospital, Bethesda, Maryland; 4 Illumina, Inc., San Diego, California; and 5 School of Medicine, University of California-San Francisco, San Francisco, California

Requests for reprints: Paul S. Meltzer, Room 6138, 37 Convent Drive, MSC 4265, Bethesda, MD 20892-4265. Phone: 301-496-5266; Fax: 301-480-3281; E-mail: pmeltzer{at}mail.nih.gov.

Key Words: follicular lymphoma • methylation profiling • epigenetics • FFPE • pathology

Emerging technologies allow broad profiling of the cancer genome for differential DNA methylation relative to benign cells. Herein, bisulfite-modified DNA from lymph nodes with either reactive hyperplasia or follicular lymphoma (FL) were analyzed using a commercial C/UpG genotyping assay. Two hundred fifty-nine differentially methylated targets (DMT) distributed among 183 unique genes were identified in FL. Comparison of matched formalin-fixed, paraffin-embedded and frozen surgical pathology replicates showed the complete preservation of the cancer methylome among differently archived tissue specimens. Analysis of the DMT profile is consistent with a pervasive epigenomic remodeling process in FL that affects predominantly nonlymphoid genes. [Cancer Res 2009;69(3):758–64]




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Functional analysis of 5-lipoxygenase promoter repeat variants
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[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2009 by the American Association for Cancer Research.