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Effects of an Antireticular Cytotoxic Serum on the Brown-Pearce Carcinoma of the Rabbit^*

David Movitz, M.D., Otto Saphir, M.D. and Alfred A. Strauss, M.D.

(From the Department of Pathology, Michael Reese Hospital, Chicago 16, Illinois)

Administration of a reticulo-endothelial tissue antiserum, previously known to affect reticulo-endothelial tissue directly by in vitro tissue culture, was followed by definite effects on the degree of malignancy of the Brown-Pearce carcinoma in vivo. Reticulo-endothelial cytotoxic serum may be given in doses that apparently produce stimulation instead of a cytotoxic effect. The cytotoxic effect of the serum on the Brown-Pearce carcinoma was indirectly and presumably well demonstrated in the first three series by producing definitely enhanced malignancy. A dose too minute to have an effect was observed in Series V and VI. Finally, a mild cytostimulatory effect was obtained with one-tenth the cytotoxic dose, given at 7- to 10-day intervals, as indirectly indicated by the resulting tumor inhibition.

^* Aided by a grant from the Simon Schiff Fund.

Ira Frank Research Fellow in pathology.

This department is in part supported by the Michael Reese Research Foundation.