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Further Studies on the Pathogenesis of Ovarian Tumors in Mice^*

Min Hsin Li, Ph.D. and W. U. Gardner, Ph.D.

(From the Department of Anatomy, Yale University School of Medicine, New Haven, Connecticut)

1. Granulosa-cell tumors, luteomas, and mixed tumors (granulosa and luteoma cells) developed in intrasplenic ovarian grafts in castrated male and female mice. There is apparently no strain limitation in the formation of these tumors in mice.

2. No ovarian tumors were observed in the intrasplenic grafts of ovaries in (a) unilaterally gonadectomized mice, (b) gonadectomized mice that received estradiol benzoate or testosterone propionate, or (c) gonadectomized mice with vascularized adhesion that permitted ovarian hormones to by-pass the hepatic portal circulation. The gonadal hormones are assumed to act indirectly by inhibiting the production and secretion of the pituitary gonadotrophic hormones.

3. Weekly treatment with 1 mg. of progesterone did not prevent tumor formation in intrasplenic ovarian grafts.

4. Daily injections of a gonadotrophin from the pregnant mare's serum (PMS) exerted luteinizing influence on the ovarian tumors.

5. The malignancy of the induced granulosacell tumors is shown by the ability to metastasize and the transplantability into new hosts.

6. These experimental results appear to substantiate further the assumption that prolonged stimulation by increased amounts of gonadotrophic hormones is responsible for the genesis of ovarian tumors.

^* Presented at the annual meeting of the American Association for Cancer Research, Chicago, May 16, 1947. This research has been aided by grants from the Anna Fuller Fund and the Jane Coffin Childs Memorial Fund for Medical Research.

Anna Fuller Fund Fellow in anatomy. Now at the National University of Peking, Peiping, China.

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