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Further Studies of the Immunological Properties of Polysaccharides from Serratia Marcescens (Bacillus prodigiosus)

III. Passive Immunization Against the Lethal Activity of the Polysaccharides with Fractions of Mouse Antiserum Elicited by a Single Injection of Polysaccharide^*

(From the Lankenau Hospital Research Institute and The Institute for Cancer Research, Philadelphia 30, Pennsylvania)

It has been found that passive immunization with relatively small amounts of the globulin fractions obtained from sera of mice either 3 or 14 days after a single injection of polysaccharides from Serratia marcescens afforded mice bearing sarcoma 37 pronounced protection against the lethal action of the homologous polysaccharide but not against that of the polysaccharides from a different strain of the organism.