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The Oxidation of Octanoate by Liver Homogenates from Leucemic Mice^*

Carl S. Vestling, Jesse N. Williams, Jr., Seymour Kaufman, Richard E. Maxwell and Henry Quastler

(From the Division of Biochemistry, Noyes Laboratory of Chemistry, University of Illinois, Urbana, and the Department of Radiology, Carle Hospital Clinic, Urbana, Ill.)

1. The oxidation of octanoate in normal rat liver and in C58 mouse liver homogenates has been studied.

2. Data from thirty-two C58 animals of varying leucemic state have been presented. Nineteen of these animals showed fatty acid oxidase activities less than 50 per cent of the theoretical. Thirteen of these 19 animals yielded homogenates exhibiting less than 20 per cent of the calculated activity.

3. A discussion of possible implications of these results is presented.