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A Correlation of Fluorescence of Human Urine with Benign and Malignant Growth

(From the Research Division, Department of Surgery, Maimonides Hospital, Brooklyn, New York)

Values of fluorescent intensity of a blue fluorescent substance and a red fluorescent substance respectively, were determined on samples of 24 hour urines in 400 cases, comprising controls, benign growth, pregnancy and malignant growth groups. Values were expressed as galvanometer readings (arbitrary units) and designated as B values and R values for the blue fluorescent and red fluorescent factors respectively and their relation to each other as B:R ratio. The B and R values and B:R ratios in the controls, benign growth including pregnancy and malignant growth groups were evaluated and correlated. Determinations for R and B values and B:R ratios were made upon 20 cases following radical surgery from 2 to 14 years. A group of 22 cases on whom radical surgery was performed for a wide range of malignant lesions were followed up throughout the year 1948 with frequent determinations of the R and B values and B:R ratios and correlated with the changes in the clinical course, such as extension of malignancy and advent of metastases.