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The Evaluation of Diagnostic Tests for Cancer

II. Inhibition of Serum Alkaline Phosphatase by Zinc Ion (The Roche Test)^*

(From the Cancer Research and Cancer Control Unit of the Department of Surgery and the Departments of Medicine and Biochemistry, Tufts College Medical School, Boston 11, the Division of Clinical Research of the Jewish Memorial Hospital, Roxbury, and the Cancer Research Laboratories of the Holy Ghost Hospital, Cambridge, Massachusetts)

Serum alkaline phosphatase from subjects with and without cancer was inhibited by zinc sulfate (1 x 10^-5 M) to the same extent. These data contrast with those of Roche in which the normal group showed no change or an activation of serum alkaline phosphatase by zine ion.