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Studies of the Recombination of Nucleic Acids with a Tissue Polypeptide^*

George T. Lewis , Ph.D., Walter L. Bloom , M.D. and Charles W. Smart , M.S.

(From the Department of Biochemistry, Emory University School of Medicine, Emory University, Georgia)

A precipitate is formed when solutions of BPP are mixed with solutions of RNA or of DRNA.These precipitates have been analyzed for nitrogen and for phosphorus, and the N/P ratio isfound to behave characteristically for each of the nucleic acids when varying proportions of thereactants are employed. With the desoxy type the ratio remains fixed, while in the case of the ribose form it varies markedly. This might suggest that in the cell nucleus, only one type of nucleoprotein (desoxyribonucleic acid+basic protein) is formed, regardless of the relative amounts of nucleic acid and protein present. The differences in this nucleoproteinwould thus appear to depend upon the type polymer of nucleic acid and not upon the nucleicacid-protein bond. On the other hand, the corresponding combination in the cytoplasm mightgive rise to a series of compounds containing differing proportions of the components.

^* Aided by a grant from the Georgia Division of the American Cancer Society.

From the Departments of Biochemistry and Medicine, Emory University School of Medicine.