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Splenic Lymphosarcomas in Rats Bearing Intrasplenic Implants of Butter Yellow^*

(From the Division of Pathology, University of California Hospital, San Francisco 22, California)

Five neoplasms of the spleen, classified as lymphoblastic lymphosarcomas, occurred among28 rats bearing intrasplenic pellets of p-dimethylaminoazobenzene, none occurring in the controls. Two of these tumors had metastasized at the time that the animals were sacrificed, the last after 461 days. The local tissue reaction and the cells involved in the consequent neoplastic growth are described, and the significance of this process in the nature of lymphosarcoma is discussed.

^* Aided by a grant from Christine Breon Fund for Medical Research.