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Some Effects of Long-continued Estrogen Treatment on Male Dutch Rabbits^*

Howard A. Bern , Ph.D.

(From the Department of Zoölogy, University of California, Los Angeles 24, California)

Summary and Conclusions: A series of male Dutch rabbits, intact and castrate, was subjected to continuous treatment with estradiol and estradici dipropionate for periods of 159 to 633 days. Dramatic change occurred in the sex accessories and in the duct system. The seminal vesicles were tremendously enlarged, and the epithelium of the prostate, vesicular gland, and seminal vesicle underwent metaplasia to a nonsquamous, transitionoid type, adenomatous in appearance. No abdominal fibroids or prostatic fibromyoepitheliomas, as reported in the guinea pig, were found; but tumorous changes (fibromas and invasive epithelial proliferations) hitherto undescribedin male mammals after estrogenization were noted in the vasa deferentia and in the epididymides of certain rabbits. In addition, striking hypertrophy of the rectum was seen in two rabbits.

^* Aided by a Research Grant from the University of California Board of Research.

Present address: Department of Zoölogy, University of California, Berkeley 4, California.