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Histological Appearance of Mouse Sarcoma 180 Infected by Vaccinia Virus^*

(From the Department of Medicine, College of Physicians and Surgeons, Columbia University, and the Presbyterian Hospital in the City of New York)

Transplants in mice of mouse sarcoma 180, parasitized by vaccinia virus and found to grow less well than control transplants, revealed no Guanieri or elementary bodies in the tumor cells or surrounding stroma. In infected tumors there was no inflammatory reaction which might be attributed to the presence of the virus.

The differences observed between infected and noninfected tumors were quantitative rather than qualitative. Mitotic figures in infected tumors were fewer than in control tumors during the first 10 days after transplant. Variations in differentiation occurred in control and infected tumors but were more common in the latter.

^* These investigations have been aided by a grant from the Jane Coffin Childs Memorial Fund for Medical Research.