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The Effect of Diethylstilbestrol on the Incidence of Leukemia in Male Mice of the Rockefeller Institute Leukemia Strain (R.I.L.)

(From the Laboratories of the Rockefeller Institute for Medical Research, New York 21, New York)

The Rockefeller Institute (Leukemia strain of mice shows a consistently higher incidence of the disease in females than in males. The rate in normal males during the period of the present study was 41.5 per cent and the females 70. Prolonged treatment of male mice with stilbestrol increased the rate to 71 per cent, a close approximation to that shown by the control females. It is suggested that this result is due to the interference with the male sex hormone rather than to a direct action of the estrogen.