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The Citric Acid Content of Tumor Tissue and of Tumor-bearing Rats^*

(From the Department of Biochemistry, School of Medicine and Dentistry, University of Rochester, Rochester, New York)

1. Walker 256 rat tumors contained more citric acid in the nongrowing center than in the growing periphery.
   
2. Aconitase activity was present in the peripheral tissue but was completely absent from thecenter.
   
3. The citric acid content of the peripheral tumor tissue was inversely proportional to thesize of the tumor.
   
4. Plasma, liver, kidney, and spleen of rats bearing tumor were higher in citric acid than weresimilar tissues of "non-take" rats.
   

^* This investigation was supported by a grant from the Donner Foundation. Presented in part at the Thirty-eighth Annual Meeting of the American Association for Cancer Research, Inc., at Chicago, May, 1947.