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The Distribution of Radioactivity in Tumor-bearing Mice after Injection of Radioactive Iodinated Trypan Blue^*

(From the Gastric Laboratory, Department of Internal Medicine, College of Medicine and Laboratory of Radiochemistry, University of Cincinnati, Cincinnati, Ohio)

The distribution of radioactivity in the tissues of 24 Swiss A mice, each bearing two subcutaneous implants of tumor 15091a, and 5 control mice was measured after intravenous injection of a radioactive dye mixture prepared by iodination of trypan blue in the presence of radioactive iodide. The tumor tissue showed several times as high a concentration of radioactivity as did the skeletal muscle or skin, but less than the liver, spleen, or kidneys. The data are compared with those obtained by others using radio-brominated trypan blue and Evans blue to show the similar behavior of these different radioactive dye preparations.

^* Aided by grants from the American Cancer Society (Hamilton County Branch), the Jane Coffin Childs Memorial Fund for Medical Research, the National Cancer Institute, and the Henry Meis Fund.