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Carbamates in the Chemotherapy of Leukemia

VI. The Influence of Urethan and Blood Acid-Base Equilibrium on Mouse Chloroleukemia 1394^*

(From the Southern Research Institute, Birmingham, Alabama)

1. The temporary experimental urethan-alkalosis reported by Hawkins and Murphy has been confirmed.

2. Treatment with sodium bicarbonate and ammonium chloride at levels which will temporarily affect the blood acid-base balance failed to significantly increase the survival time of mice with transmitted chloroleukemia 1394.

3. Administration of ammonium chloride concomitantly with urethan for the purpose of temporarily overcoming urethan alkalosis did not appear to adversely affect the anti-leukemic action of urethan for chloroleukemia 1394 in mice.

^* This investigation was carried out under a Grant-in-Aid from the American Cancer Society upon recommendation of the Committee on Growth of the National Research Council, and grants from Mr. Ben May, Mobile, Alabama, and the Institute-Sponsored Research Fund of Southern Research Institute.