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Distribution of Tracer Doses of Methionine Tagged with Radiosulfur in Normal and Neoplastic Tissue^*

(^** From the Department of Surgery, University of Minnesota Medical School, Minneapolis, Minnesota)

1. The distribution of tracer doses of d-l-methionine tagged with radiosulfur has been studied in mice with spontaneous and transplanted neoplasms.

2. These studies indicate a high initial concentration of radiomethionine results in liver, tumor, kidney and intestinal wall.

3. Any therapeutic possibilities relating to introducing radioactive sulfur into tumor cells must await animal trial.

^* Supported by the following research grants: Malignant Disease Research Fund and a grant from the Graduate School of the University of Minnesota.