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The Preparation and Properties of the Mitochondria and Submicroscopic Particles of Normal and Leukemic Mouse Organs^*

(From the Sloan-Kettering Institute for Cancer Research, New York 21, New York)

1. The mitochondria of normal and leukemic mouse spleen and liver have been isolated by centrifugation in 0.88 M sucrose. A fraction of similar sedimentation properties, but lower nucleic acid content, has been isolated from mouse kidney.

2. A fraction consisting of the largest submicroscopic nucleoprotein particles has been prepared from normal and leukemic spleen, liver, and kidney, and its nucleic acid content determined.

^* The expenses of this investigation were defrayed by grants from the Office of Naval Research, the James Foundation of New York, Inc., the Barker Welfare Foundation of New York, and the Finney-Howell Research Foundation.