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Intraocular Transplantation of Malignant Lymphomas of the Mouse, Dog, and Man in Heterologous Species

(From the Department of Pathology, University of Chicago, Chicago 37, Illinois)

Intraocular transplantations in 7 cases of human malignant lymphomas (leukemia, lymphosarcoma, and Hodgkin's disease), 1 canine malignant lymphoma, and 2 leukemias of mice were unsuccessful in alien species (guinea pigs, rabbits, dogs, and mice). The mouse leukemias were transplantable in the eyes of homologous and heterologous strains of mice, but regression of the disease occurred rapidly in the latter strain. Histologic fate of transplants was rapid necrosis and partial resorption followed by organization of the debris.

The interpretation given to these experiments is that the failure of successful intraocular transplantation of malignant lymphomas in alien species was the result of the short life span of the cells, their high susceptibility to adverse conditions, and their antibody-engendering capacity, rather than to lack of a high degree of malignancy and autonomy.

This procedure was not of value in differential diagnosis.