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Hypervolemia and Associated Changes in Mice Bearing a Transplanted Granulosa Cell Tumor^*

E. E. Cliffton, M.D. and J. T. Wolstenholme, M.D.

(From the Departments of Surgery and Anatomy, Yale University School of Medicine, New Haren 11, Connecticut)

1. Mice bearing a transplanted granulosa cell tumor have hypervolemia and associated sinusoidal dilatation in the liver, spleen, and adrenal glands.

2. An estrogenic effect, as evidenced by vaginal smears and enlargement of the uteri, was noted in castrated female animals bearing this tumor.

3. Enlargement of the seminal vesicles and prostate was observed in castrated, tumor bearing males.

^* This investigation was supported by a research grant from the U.S. Public Health Service and a fellowship grant from the American Cancer Society.

Senior Research Fellow, American Cancer Society.

Post-doctorate Research Fellow, National Institute of Health.