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Preparation of a Radioactive Iodotetrazolium Salt and Its Distribution in Mice^{* ,}

(From the Kirstein Laboratory for Surgical Research, Beth Israel Hospital, Boston, and the Department of Surgery, Harvard Medical School, Boston, Massachusetts)

The synthesis of 0.01 millimole of diphenyl p-iodophenyl tetrazolium chloride from radioactive iodine (I¹³¹) is described. Following the intravenous injection of the radioactive tetrazolium salt into normal and tumor-bearing mice, radioactivity disappeared rapidly from the circulating blood, and appeared in greatest amount in kidney, liver, and lung. Sarcoma 37 contained less radioactivity than most other tissues.

^* This investigation was aided by a research grant from the National Cancer Institute, National Institutes of Health, U.S. Public Health Service.

Acknowledgment is due Mr. Myron Milden for technical assistance.

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				E. Atkinson, S. Melvin, and S. W. Fox Some Properties of 2,3,5-Triphenyltetrazolium Chloride and Several Iodo Derivatives Science, April 14, 1950; 111(2885): 385 - 387. [PDF]