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Infiltrating Adenomatous Lesions of the Stomach, Cecum, and Rectum of Monkeys Similar to Early Human Carcinoma and Carcinoma in situ^*

Clarence C. Lushbaugh, M.D.

(From the Department of Pathology and the Toxicity Laboratory, University of Chicago, Chicago 37, Illinois)

Previous observations on the occurrence of infiltrating hyperplastic gastric mucosal lesions in rhesus monkeys who had ingested diesel motor lubricating oil are extended by additional examples of the disease. Similar lesions are produced in the colon by the same means. Two instances of similar but apparently naturally occurring gastric lesions in monkeys are reported. These lesions are described and their nature is discussed. Their similarity to human disease and, in several instances to human gastric and colonic carcinoma, are pointed out. These lesions are considered in the absence of incontrovertible proof not to be malignant neoplasms in spite of their morphological appearance.

^* Part of this work was done under contract between the University of Chicago Toxicity Laboratory and the Medical Division, Chemical Corps, U.S. Army which neither restricts nor is responsible for the opinions or conclusions of the author.

This fund also defrayed the added cost of the supernumerary photomicrographs illustrating this article.

Present address: Los Alamos Scientific Laboratory, Los Alamos, New Mexico.