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A Lymphopenia-Causing Agent, Probably a Virus, Found in Mice After Injection with Tumor Tissue and with Cell-free Filtrates of Lymphosarcoma T 86157 (MB)

(From the Laboratory of the Antoni van Leeuwenhoek-huis, Netherlands Cancer Institute, Amsterdam)

1. A lymphopenia was observed to develop in mice on the second day following injection of minced tumor tissue of lymphosarcoma T 86157 (MB).

2. It was shown that a tumor could be produced in mice without a concomitant lymphopenia.

3. Lymphopenia without tumor was produced in mice injected with cell-free filtrate of sarcoma MB.

4. Lymphopenia without tumor was also produced by injection of minced organs derived from mice previously injected with cell-free filtrate of sarcoma MB.

5. It is concluded that a filtrable agent, probably a virus, is responsible for the lymphopenia produced. This virus seems to bear no relationship to the presence of the tumor.