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Mechanism of Induction of Ovarian Tumors by X-Rays^*

Louis Lick, M.D., Arthur Kirschbaum, Ph.D., M.D. and Harry Mixer, M.S., M.D.

(From the Departments of Anatomy and Radiology, University of Minnesota, Minneapolis 14, Minnesota)

X-rays did not induce tumor development in a radiated ovary of the Bagg albino stock if the animal's second ovary remained unirradiated and functional. Contact radiation of a single ovary induced ovarian tumor development only if the second ovary was extirpated. Bilateral contact radiation resulted in tumor development. Although a second functioning ovary inhibited ovarian tumor development following unilateral contact radiation, a granulosa cell tumor developed spontaneously in a non-irradiated ovary containing two fully developed ovarian follicles.

^* This investigation has been aided by grants from the National Cancer Institute, The Jane Coffin Childs Memorial Fund for Medical Research, and the Cancer Fund of the Graduate School of the University of Minnesota.

Submitted in partial fulfillment of the requirements for the degree of Master of Science at the University of Minnesota.