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Cancer Research 69, 5619, July 15, 2009. Published Online First June 30, 2009;
doi: 10.1158/0008-5472.CAN-09-1351
© 2009 American Association for Cancer Research
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Commentary

Polyps Wrap Mast Cells and Treg within Tumorigenic Tentacles

Mario P. Colombo and Silvia Piconese

Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico "Istituto Nazionale dei Tumori," Milan, Italy

Requests for reprints: Mario P. Colombo, Molecular Immunology Unit, Department of Experimental Oncology, Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico "Istituto Nazionale dei Tumori," Via Venezian 1 20133 Milan, Italy. Phone: 39-02-2390-2252; Fax: 39-02-2390-2630; E-mail: mario.colombo{at}istitutotumori.mi.it.

Abstract

Gounaris and colleagues describe a previously unrecognized cross-talk between mast cells and Treg in colon adenomatous polyposis (Gounaris et al., Cancer Res 2009;69:5490–7). Adoptively transferred Treg suppress the focal mastocytosis that fosters tumor initiation and progression. In contrast, endogenous Treg, which abundantly infiltrate polyps, show proinflammatory activity under unknown microenvironmental cues that promote mast cell differentiation and expansion. Compartmentalized Treg plasticity seems to be a key factor in establishing the optimal milieu for cancer development in the intestines. Treg partnership with mast cells recapitulates the complexity of innate-adaptive networks characterizing gut inflammation and represents a novel target for cancer immunotherapy. [Cancer Res 2009;69(14):5619–22]


Related Article

T-Regulatory Cells Shift from a Protective Anti-Inflammatory to a Cancer-Promoting Proinflammatory Phenotype in Polyposis
Elias Gounaris, Nichole R. Blatner, Kristen Dennis, Fay Magnusson, Michael F. Gurish, Terry B. Strom, Philipp Beckhove, Fotini Gounari, and Khashayarsha Khazaie
Cancer Res. 2009 69: 5490-5497. [Abstract] [Full Text] [PDF]





HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2009 by the American Association for Cancer Research.