Table 2 Results of tissue array immunohistochemistry of 3439 individual tumors of >100 different types for POU5F1
The organ (in alphabetic order), tumor type, number of cases studied, and positive findings are indicated
| Organ |
Tumor |
Subgroup |
n |
Positive |
|
| Adrenal gland |
Carcinoma |
Adeno- |
19 |
0 |
| Anus |
Carcinoma |
Squamous |
3 |
0 |
| Brain |
|
Gliobl. multif./astrocytoma/ |
46/35 |
0 |
|
|
oligodendroglioma/meningioma/ |
24/46 |
0 |
|
|
PNET/ependymoma/ |
17/9 |
0 |
|
|
gangioneuroma/ |
7 |
0 |
|
|
medulloblastoma/estioneuroblastoma/ |
4/2 |
0 |
|
|
opticus glioma/cranioph.a |
1/8 |
0 |
| Carotid body |
Glomus tumor |
|
11 |
0 |
| Cervix |
Carcinoma |
Squamous/CIS/adeno |
37/7/4 |
0 |
| Colon |
Adenoma |
Tubular and villous |
134 |
0 |
|
Carcinoma |
Adeno- |
47 |
0 |
| Endometrium |
Carcinoma |
Adeno- |
61 |
0 |
|
Sarcoma |
Endometrial stromal sarcoma |
3 |
0 |
| Esophagus |
Carcinoma |
Squamous/adeno |
21/116 |
0 |
| Gall bladder |
Carcinoma |
Adeno- |
23 |
0 |
| Glomus tumor |
|
|
11 |
0 |
| Kidney |
Carcinoma |
Clear cell/papillary |
50/45 |
1/0 |
|
|
Chromophobic |
13 |
0 |
|
Oncocytoma |
|
7 |
0 |
| Larynx |
Carcinioma |
Squamous |
46 |
0 |
| Liver |
Carcinoma |
Hepatocellular |
41 |
0 |
| Lung |
Carcinoma |
Adeno-/squamous/ |
48/50 |
0/1 |
|
|
large cell/small cell |
47/41 |
1/0 |
| Lymph nodes |
Lymphoma |
Hodgkins |
50 |
0 |
|
|
Non-Hodgkins high/low grade |
69 |
0 |
|
|
MALT |
42 |
0 |
| Breast |
Carcinoma |
Lobular/ductal |
42/46 |
0 |
|
|
Med./muc./tub. |
27/23/26 |
0 |
|
|
Cribriform/apocrine |
5/3 |
0 |
|
Phylloidees tumor |
|
13 |
0 |
| Mouth |
Carcinoma |
Squamous |
57 |
0 |
| Ovary |
Carcinoma |
Endometroid/serous mucinous |
49/48/20 |
0 |
|
|
Brenner/mixed Müllerian tumor |
9/6 |
0 |
|
Granulosa cell |
|
7 |
0 |
|
Dysgerminoma |
|
2 |
2 |
|
Gonadoblastoma |
|
1 |
1 |
| Pancreas |
Carcinoma |
Adeno- |
47 |
0 |
| Paraganglia |
Paraganglioma |
|
10 |
0 |
| Parathyroid |
Carcinoma |
Adeno- |
20 |
0 |
| Parotid gland |
Carcinoma |
Mixed |
15 |
0 |
|
|
Acinic cell/mucoepithelial |
5/6 |
0 |
| Phaeochrom. |
|
|
26 |
0 |
| Penis |
Carcinoma |
Squamous |
43 |
0 |
| Prostate |
Carcinoma |
Adeno-, horm. (non-)refract. |
200 |
0 |
|
PIN/BPH |
|
24/18 |
0 |
| (Small) salivary gland |
Pleom. adenoma |
|
49 |
0 |
|
Lymphoep. lesion |
|
5 |
0 |
|
Carcinoma |
Adenoid cystic |
43 |
0 |
|
|
Acinic cell |
36 |
0 |
|
Adenolymph. |
|
30 |
0 |
| Skin |
Carcinoma |
Squamous/basal |
81/37 |
0 |
|
Melanoma |
|
44 |
0 |
|
Merkel cell tumor |
|
6 |
0 |
|
Benign |
Hemangioblastoma |
8 |
0 |
|
|
Nevus |
38 |
0 |
|
|
Appendix tumors |
25 |
0 |
| (Small) intestine |
Carcinoma |
Adeno- |
17 |
0 |
|
GIST |
|
14 |
0 |
| Stomach |
Carcinoma |
Intestinal/diffuse |
44/23 |
0 |
| Soft tissue |
Benign |
Lipoma/fibrous histiocytoma/Schwann/ |
15/58/35 |
0 |
|
|
neurofibroma/leiomyoblastoma/ |
31/7 |
0 |
|
|
giant cell tumors of tendon sheet/ |
29/ |
0 |
|
|
hemangioma |
17 |
0 |
|
Intermediate |
Haemangiopericytoma |
8 |
0 |
|
|
Dermatofibrosarcoma protuberans |
2 |
0 |
|
Malignant |
Kaposi/liposarcoma |
25/26 |
0 |
|
|
Angiomyolipo./malign. Schwann. |
1/8 |
0 |
|
|
Rhabdomyosarcoma/synovial sarcoma |
13/3 |
0 |
|
|
Angios./fibros./alv. soft part sarc. |
4/6/1 |
0 |
|
|
Epithelioid sarcoma |
2 |
0 |
| Testis |
|
Seminoma/nonseminoma |
49/47 |
49/33b |
|
|
Adenomatoid tumor |
10 |
0 |
| Thyroid |
Carcinoma |
Foll./papill./med. |
42/48/36 |
0 |
| Thymus |
Thymoma |
|
23 |
0 |
| Urinary bladder |
Carcinoma |
TCC |
101 |
0 |
|
|
Small cell/squamous/adeno- |
3/5/4 |
0 |
|
Sarcoma |
|
7 |
0 |
| Uterus |
Myoma |
|
107 |
0 |
| Vagina |
Carcinoma |
Squamous |
5 |
0 |
| Vulva |
Carcinoma |
Squamous |
37 |
0 |
| Various |
Carcinoid |
|
48 |
0 |
|
Adenomatoid tumor |
|
10 |
0 |
|
Mesothelioma |
|
23 |
0 |
| Controlsc |
|
|
30 |
0 |
|
a Gliob. multif., glioblastoma multiforme; PNET, primitive neuro-ectodermal tumor; cranioph, craniopharyngioma; CIS, carcinoma in situ; MALT, mucosa associated lymphoid tissue; med, medullar; muc, mucinous; tub, tubular; horm (non-)refract, hormonal (non)refractory; angiomyolipo., angiomyoliposarcoma; malign. Schwann., malignant Schwannoma; anglo., angiosarcoma; fibros., fibrosarcoma; alv. soft part sarc., alveolar soft part sarcoma; foll., follical.
b If containing seminoma in case of combined tumors or embryonal carcinoma elements.
c Included in all seven slides: skin (n = 4); lymph node (n = 2); heart (n = 2); skeletal muscle (n = 2); smooth muscle (n = 2); myometrium (n = 2); thyroid gland (n = 2); liver (n = 2); kidney cortex (n = 2); prostate (n = 2); testis (n = 2); submand. gland (n = 2); proliferative endometrium (n = 2); gray matter cerebrum (n = 2).