Cancer Research 64, , , . doi:
© 2009 American Association for Cancer Research
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Fig. 3. PAX5 expression in a case of myeloid leukemia bearing the t(8;21) translocation. Diffuse marrow infiltration by t(8;21)-AML blasts (top left panel; H&E; x800) strongly expressing the myeloperoxidase molecule (top right panel; x800). In the bottom left panel (x800), a percentage of leukemic cells shows nuclear expression of PAX5 (double arrow); the single arrow points to a PAX5-negative leukemic cell, and the arrowhead points to a PAX5-positive residual mature B lymphocyte. In the bottom right panel (x800), a proportion of t(8;21)-leukemic cells shows cytoplasmic positivity for CD79a (x800); three leukemic cells clearly coexpressing PAX5 (nuclear brown positivity) and CD79a (cytoplasmic blue positivity) are shown in the inset (immunoperoxidase/alkaline phosphatase antialkaline phosphatase complex technique). Top right panel and bottom panels: alkaline phosphatase antialkaline phosphatase complex technique and hematoxylin counterstain.
