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100 µg/kg QOD x 3a 200 µg/kg QOD x 3 Normal Day 1b Day 5 Day 8 Day 1b Day 3 Day 5 Day 8 Day 15 Protein, total (g/dl) 7.8 7.2 7.2 6.1 6.2 6 5.8 6.2 6–8.5 Albumin (g/dl) 3.9 3.3 3 3.3 3 2.5 2.6 3.1 3.2–5.2 Glucose (mg/dl) 64 64 78 63 85 74 69 60 60–120 Sodium (mM) 145 147 147 142 146 144 147 142 145–152 Potassium (mM) 4 4.1 4.6 3.8 4.1 4.4 4 3.8 3–4.5 Chloride (mM) 109 111 105 105 107 108 109 105 105–115 Calcium (mM) 2.35 2.39 2.48 2.21 2.32 2.21 2.2 2.29 2.1–2.55 Magnesium (mM) 0.76 0.74 0.7 0.79 0.69 0.85 0.75 0.81 0.65–1 Creatinine (mg/dl) 0.9 1 1 0.9 0.9 0.9 0.9 0.9 0.5–1.1 BUN (mg/dl) 18 16 10 29 14 13 30 19 10–32 Creatine kinase (units/liter) 435 684 783 547 172 480 318 196 24–1000 Alkaline phosphatase (units/liter) 72 112 153 82 202 323 319 168 150–464 ALT (units/liter) 31 25 23 45 92 139 110 42 0–60 AST (units/liter) 27 33 20 36 53 73 50 30 0–100 Lactose dehydrogenase (units/liter) 323 569 278 181 361 380 313 196 100–446

^a QOD x 3, every other day 3 times injection; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BUN, blood urea nitrogen.

^b Day 1 was the first day of 8H9(dsFv)-PE38 administration.

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