Cancer Research CTRC-AACR San Antonio Breast Cancer Symposium Translational Medicine Conference in Israel
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[Cancer Research 66, 3345, March 15, 2006]
© 2006 American Association for Cancer Research

Corrections

TGF-ß Pathway Variants and Breast Cancer Risk

In the article on TGF-ß pathway variants and breast cancer risk in the April 15, 2005 issue of Cancer Research (1), several sections of text were incorrect. On page 3457, the last two sentences in the last paragraph before the Discussion should have read as follows: "On the contrary, both TGFB1*CT and TGFB1*CC were less likely to have advanced stage as assessed by the presence of lymph node metastasis and stage III or IV at diagnosis (Table 4). Patients carrying the TGFB1*CC genotype were less likely to have ER and PR negative tumors (Table 4)." On page 3458, the last sentence of the first paragraph in the right-hand column should have read as follows: "In our report the lower frequency of lymph node metastases and the less advanced stage at diagnosis in carriers of the TGFB1*CC and TGFB1*CT genotypes is in agreement with the laboratory findings that increased TGF-ß signaling impairs mammary tumorigenesis (8). The recent report of a significantly reduced 5-year survival among patients with breast cancer that carry the TGFB1*CC and TGFB1*CT genotype (40) is consistent with the laboratory findings that increased TGF-ß signaling promotes metastasis of established breast tumors (8)." On page 3458, the first sentence of the second paragraph in the right-hand column should have read as follows: "Taken together these results are additional evidence that increased TGF-ß signaling due to a naturally occurring variants is initially associated with a less aggressive tumor behavior but may enhance the growth of metastases." On page 3458 and continuing onto page 3459, the last sentence of the second paragraph in the right-hand column on page 3458 should have read as follows: "The additional finding of an increased proportion of ER and PR negative tumors among carriers of the TGFB1*CC genotype point to the fact that increased TGF-ß signaling results in less aggressive tumor behavior in the absence of ER and PR overexpression." On page 3459, the second sentence of the first full paragraph on that page should have read as follows: "Hence, the growth of ER and PR negative tumors from premenopausal women may be affected by increased TGFB1 levels, whereas growth of the predominantly ER and PR positive tumors from postmenopausal women may not be similarly affected by higher TGFB1 levels."

References

  1. Kaklamani VG, Baddi L, Liu J, Rosman D, Phukan S, Bradley C, Hegarty C, McDaniel B, Rademaker A, Oddoux C, Ostrer H, Michel LS, Huang H, Chen Y, Ahsan H, Offit K, Pasche B. Combined genetic assessment of transforming growth factor-ß signaling pathway variants may predict breast cancer risk. Cancer Res 2005;65:3454–61.[Abstract/Free Full Text]




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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online