Suppressor of Cytokine Signaling 3 Promotes Bone Marrow Cells to Differentiate into CD8⁺ T Lymphocytes in Lung Tissue via Up-Regulating Notch1 Expression

Departments of ¹Immunology and ²Pathology, Nankai University School of Medicine; ³Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin, People's Republic of China

^* To whom correspondence should be addressed. E-mail: ryang{at}nankai.edu.cn.

	Abstract

Suppressor of cytokine signaling 3 (SOCS3) expression in bone marrow cells (BMC) was up-regulated upon exposure to interleukin 6, lipopolysaccharide, or tumor-associated factors. But, how the up-regulated SOCS3 affects differentiation of BMCs is incompletely characterized. Here, we showed that SOCS3 promoted BMCs to intently differentiate into CD8 T cells. Importantly, lung can be as one athymus tissue for the BMCs to differentiate into CD8⁺ T cells. Notch1 plays a critical role in the differentiation from SOCS3-transfected BMCs to CD8⁺ T cells. We conclude that the up-regulated SOCS3 in some pathologic conditions, such as tumor and inflammation, might promote BMCs to differentiate into CD8⁺ T lymphocytes in lung tissue via up-regulating Notch1 expression. This may represent a new mechanism against diseases such as tumor. [Cancer Res 2009;69(4):1578–86]

Key Words: suppressor of cytokine signaling 3, Notch1, CD8⁺ T cell, bone marrow cell, lung tissue