This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kawakami, K. Articles by Puri, R. K. Search for Related Content PubMed PubMed Citation Articles by Kawakami, K. Articles by Puri, R. K.

Targeting Interleukin-4 Receptors for Effective Pancreatic Cancer Therapy¹

Laboratory of Molecular Tumor Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892

We demonstrate that pancreatic cancer tissues express receptors for interleukin (IL)-4 in situ at highdensity. Using the approach of selective receptor targeting, we have tested the efficacy of a recombinant cytotoxin IL4-Pseudomonas exotoxin A, which is composed of a targeting moiety (IL-4) and a mutated form of Pseudomonas exotoxin. Our results demonstrate that this molecule exerts vigorous antitumor activity against human pancreatic tumors implanted s.c. in immunodeficient animals. Sixty percent of animals treated with intratumoral injections of IL4-Pseudomonas exotoxin A experienced complete disappearance of established tumors. Animals with pancreatic tumors implanted orthotopically exhibited prolonged survival that was significantly greater by comparison with untreated animals. Thus, IL-4 receptor-targeted cytotoxin represents a potent agent that may provide an effective therapy for pancreatic cancer.

This article has been cited by other articles:

				T. Shimamura, R. E. Royal, M. Kioi, A. Nakajima, S. R. Husain, and R. K. Puri Interleukin-4 Cytotoxin Therapy Synergizes with Gemcitabine in a Mouse Model of Pancreatic Ductal Adenocarcinoma Cancer Res., October 15, 2007; 67(20): 9903 - 9912. [Abstract] [Full Text] [PDF]

				M. Kioi, S. Takahashi, M. Kawakami, K. Kawakami, R. J. Kreitman, and R. K. Puri Expression and Targeting of Interleukin-4 Receptor for Primary and Advanced Ovarian Cancer Therapy Cancer Res., September 15, 2005; 65(18): 8388 - 8396. [Abstract] [Full Text] [PDF]

				M. Kawakami, K. Kawakami, M. Kioi, P. Leland, and R. K. Puri Hodgkin lymphoma therapy with interleukin-4 receptor-directed cytotoxin in an infiltrating animal model Blood, May 1, 2005; 105(9): 3707 - 3713. [Abstract] [Full Text] [PDF]

				K. Kawakami, M. Kawakami, S. R. Husain, and R. K. Puri Effect of Interleukin (IL)-4 Cytotoxin on Breast Tumor Growth after in Vivo Gene Transfer of IL-4 Receptor {alpha} Chain Clin. Cancer Res., May 1, 2003; 9(5): 1826 - 1836. [Abstract] [Full Text] [PDF]

				S. R. Husain, K. Kawakami, M. Kawakami, and R. K. Puri Interleukin-4 Receptor-targeted Cytotoxin Therapy of Androgen-dependent and -independent Prostate Carcinoma in Xenograft Models Mol. Cancer Ther., March 1, 2003; 2(3): 245 - 254. [Abstract] [Full Text] [PDF]