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[Cancer Research 62, 1862-1867, March 15, 2002]
© 2002 American Association for Cancer Research

Tumor Biology

Noninvasive Imaging of Spontaneous Retinoblastoma Pathway-dependent Tumors in Mice1

Marc Vooijs2, Jos Jonkers, Scott Lyons and Anton Berns3

Division of Molecular Genetics and Centre for Biomedical Genetics, The Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands

Identification of the critical pathways involved in tumorigenesis should ultimately lead to the design of better anticancer agents that target specific componentsof the disrupted pathways. Murine models of spontaneous cancer in which tumor formation is dependent on defined genetic alterations provide a powerful test system for evaluating the therapeutic efficacy of pathway-specific antineoplastics. We have generated a conditional mouse model for retinoblastoma-dependent sporadic cancer that permits noninvasive monitoring of pituitary tumor development in live animals via in vivo bioluminescence imaging of luciferase expression. We show that the high sensitivity of bioluminescence imaging can be used for noninvasive detection of luciferase expression in pituitary glands from tumor-free animals and for in vivo quantitation of tumor burden over a large dynamic range. This mouse model permits longitudinal monitoring of tumor onset, progression, and response to therapy and may be used effectively for testing cancer prevention and treatment strategies based on therapeutics that specifically target the retinoblastoma pathway.




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Copyright © 2002 by the American Association for Cancer Research.